Current drug-eluting stents used in the treatment of myocardial ischaemia are unsuitable for all lesion types, and have been associated with endothelial The aim of this work was to develop a novel prostacyclin analogue eluting stent, which would represent a significant advance on existing devices by virtue of a superior biological profile, and optimal release kinetics. The functional effects of leading prostacyclin analogues were assessed on isolated pig coronary and rabbit iliac arteries. AFP07 produced relaxation and contraction in both arteries, whilst cicaprost produced relaxation with no evidence of contraction. Antagonists were used to demonstrate the presence of prostanoid IP receptors mediating relaxation, and contractile EP] and EP3 receptors in each artery bed. Differences in functional responses between analogues were found to be due to differences in activity at E type receptors, with cicaprost being the most selective IP receptor agonist studied.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:501896 |
| Date | January 2008 |
| Creators | ristopher, Christopher |
| Publisher | University of Strathclyde |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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