World Health Organization (WHO) reported that breast cancer is the top cancer in women both in the developed and the developing countries. Although breast cancer is thought to be a disease of the developed countries, the incidence of breast cancer is increasing in developing countries, where the disease has becoming the lead ing cause of death. WHO added that the high mortality rates in less developed countries is mainly causes by majority of cases are diagnosed in late stages preventing curable treatment, as well as by the lack of adequate diagnosis and treatment facilities. Therefore, early tumour detection is very important in breast cancer management being able to improve the surviving rate. Many techniques to improve the detection of tumours in the breast have been developed in the last few years. Th is study is focusing on the dual-energy technique of contrast-enhanced digital mammography (CEDM) to aid in the detection and characterization of breast lesions. Standard dual-energy (K-edge subtraction) methodology requires two separate acquisitions to obtain two images, below and above the K-edge of a given contrast agent, and is typically implemented with a monochromatic X-ray source. This work in mammography proposes an approach using a polychromatic beam, providing for clinical applications with X-ray tubes. In particular, with a polychromatic beam produced by a microfocal X-ray source, this work is aimed at assessing the feasibility of K-edge subtraction (KES) mammography carried out in conjunction with an iodine-based contrast agent. Spectroscopic information is obtained using pixellated spectroscopic detectors.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:616487 |
| Date | January 2013 |
| Creators | Saifuddin, Sarene Chu |
| Publisher | University of Surrey |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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