Many viruses have evolved complex mechanisms to avoid or block either the induction of, or the action of interferons. Interferons (IFNs) are the main innate cytokines that are able to induce a cellular antiviral state. thereby limiting viral replication and disease pathology. Plasmacytoid dendritic cells (PDCs) are specialised interferon producing cells and play a crucial role in the control of viral infections. Here we examine the interaction of plasmacytoid dendritic cells with two viruses -both of which are capable of blocking interferon in host cells. Using density gradient separation and cell sorting, we have highly enriched a population of bovine cells capable of producing high levels of biologically active IFN. These cells represented less than 0.1 % of the total lymphocyte population in blood, pseudoafferent lymph, and lymph nodes.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:599569 |
| Date | January 2013 |
| Creators | Reid, Elizabeth |
| Publisher | University of Surrey |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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