Drug delivery systems are designed to achieve low, local doses at the target site. Delivery systems can provide the drug in a continuous manner or in response to environmental stimuli such as temperature, pH or UV.
This study aimed to develop photosensitive liposomes that achieve UV-responsive release of their content. The main mechanism was to incorporate a light sensitive molecule into the liposomal bilayer then achieve destabilization of the membrane by exposure to UV. This would result in an on demand release of the bioactive content. Suprofen, a nonstereoidal anti-inflammatory drug, also a light sensitive molecule, was selected to achieve the destabilization in this study. Lipid vesicles were prepared with different ratios of phosphatidyl choline, cholesterol and Suprofen (PC:CHOL:SPF) and characterized in terms of encapsulation efficiency, release rate and responsiveness to UV. Preliminary studies were carried out with calcein (CAL), a fluorescent dye, due to the ease of detection and the in vitro studies were carried out with the cancer drug Cisplatin.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12613711/index.pdf |
| Date | 01 September 2011 |
| Creators | Demirbag, Birsen |
| Contributors | Hasirci, Vasif |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for public access |
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