The effect of chloroethylclonidine on nodrenaline-induced contractions of the rat aorta was studied. Chloroethylclonidine (1.5 × 10-5 M) shifted noradrenaline dose-response curve to the right approximately 5000-fold without depressing the maximum. The response to noradrenaline after chloroethylclonidine was not antagonized by phenoxybenzamine (10-7 M), prazosin (10-7 M), WB 4101 (10-7 M) nor yohimbine (10-5 M) and is therefore not mediated via α1-adrenoceptors. These results would suggest that there is a homogenous population of chloroethylclonidine-sensitive α1-adrenoceptors in the rat aorta and that chloroethylclonidine treatment reveals a non-α-adrenoceptor noradrenaline binding site in this tissue.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-12956 |
| Date | 20 March 1990 |
| Creators | Oriowo, Mabayoje A., Bevan, John A. |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Source | ETSU Faculty Works |
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