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In Utero Exposure to Organochlorine Pesticides and Early Menarche in the Avon Longitudinal Study of Parents and Children

Introduction
Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited.
Methods
Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5 years of age (cases) and 230 girls who reported menarche at or after 11.5 years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI.
Results
We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche.
Conclusions
This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-1026
Date01 September 2016
CreatorsNamulanda, Gonza, Maisonet, Mildred, Taylor, Ethel, Flanders, W. Dana, Olsen, David, Sjodin, Andreas, Qualters, Judith R., Vena, John, Northstone, Kate, Naeher, Luke
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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