Zinc is widely used as an alternative to antibiotic in piglets. Recent studies demonstrated the antibacterial effect of zinc nanoparticles. It is believed that zinc nanoparticles will exhibit better antibiotic effects than previously used medication zinc. There is a need to define ZnNPs effect on the organism. This thesis compares the influence of administration of zinc oxide nanoparticles and zinc standard forms at the dose of 2000 mg/Zn/kg diet in rat organism. The antioxidant status of rats and toxicity of zinc and zinc nanoparticles were monitored. The level of accumulated zinc for blood was on average 12 mg / kg ± 6 mg / kg, for liver 74 mg / kg ± 50 mg / kg, for kidneys 37 mg / kg ± 30 mg / kg for both nanoparticles and normal zinc . ZnNPs and zinc oxide did not extremely influence antioxidant status of samples of blood, liver and kidney. A significant effect was observed with GSH levels. Histological study of liver and duodenum showed slight tissue damage after administration of both zinc and nanoparticles. Zinc nanoparticles demonstrated beneficial effects as well as standard form.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:427711 |
| Date | January 2019 |
| Creators | Jeník, David |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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