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An investigation into the role of histological parameters in the prediction of the prognosis for tl and t2 oral squamous cell carcinomas

Magister Chirurgiae Dentium (MChD) / TI and T2 squamous cell carcinomas of the head and neck have an unpredictable prognosis that
often pose therapeutic problems. Sophisticated methods such as cytometric DNA analysis,
immunocytochemistry and detection of cellular growth factors, have been applied with varying
success rates for predicting recurrences, metastatic rates and overall prognoses. However, with
the general lack of resources in Africa, devising a simple, reliable, reproducible and cost-effective
method of predicting tumour behaviour to aid optimal treatment planning is imperative. Surgical
excision specimens of forty-eight primary Tl and T2 squamous cell carcinomas of the floor of the
mouth and tongue were histologically evaluated by two individual pathologists (double-blinded
study) who had no prior knowledge of clinical course or outcome.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/9049
Date January 1998
CreatorsRoberts, Tina Sharon
ContributorsHille, Josh
PublisherUniversity of Western Cape
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
Formatapplication/pdf
RightsUniversity of Western Cape

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