Aalen’s additive hazards model has gained increasing attention in recently years because it model all covariate effects as time-varying. In this thesis, our goal is to explore the application of Aalen’s model in assessing treatment effect at a given time point with varying covariate effects. First, based on Aalen’s model, we utilize the direct adjustment method to obtain the adjusted survival of a treatment and comparing two direct adjusted survivals, with univariate survival data. Second, we focus on application of Aalen’s model in the setting of competing risks data, to assess treatment effect on a particular type of failure. The direct adjusted cumulative incidence curve is introduced. We further construct the confidence interval of the difference between two direct adjusted cumulative incidences, to compare two treatments on one risk.
| Identifer | oai:union.ndltd.org:GEORGIA/oai:digitalarchive.gsu.edu:math_theses-1044 |
| Date | 21 April 2008 |
| Creators | Akcin, Haci Mustafa |
| Publisher | Digital Archive @ GSU |
| Source Sets | Georgia State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Mathematics Theses |
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