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Identification of Endogenous Substrates for ADP-Ribosylation in Rat Liver

Bacterial toxins have been shown to modify animal cell proteins in vivo with ADPR. Animal cells also contain endogenous enzymes that can modify proteins. Indirect evidence for the existence in vivo of rat liver proteins modified by ADPR on arginine residues has been reported previously. Presented here is direct evidence for the existence of ADP-ribosylarginine in rat liver proteins. Proteins were subjected to exhaustive protease digestion and ADP-ribosyl amino acids were isolated by boronate chromatography.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc277847
Date05 1900
CreatorsLoflin, Paul T. (Paul Tracey)
ContributorsJacobson, Myron, Norton, S. J., Masaracchia, Ruthann A., Benjamin, Robert C., Wu, Edward Ming-chi, 1938-
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatxiii, 202 : ill., Text
RightsPublic, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved., Loflin, Paul T. (Paul Tracey)

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