This work examines the synthesis of poly(ADP-ribose) in normal and SV40-transformed monolayer cultures of 3T3 cells as a function of growth and DNA fragmentation. A review of the relevant literature is given in the introduction of this work. Poly(ADP-ribose) synthesis has been implicated in transcription, replication, repair, differentiation and regulation of cell growth. The results of this study suggest that poly(ADP-ribose) synthesis is involved in some aspect of cell-growth control and DNA repair.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc332216 |
| Date | 12 1900 |
| Creators | Levi, Viktorya |
| Contributors | Jacobson, Myron, Gracy, Robert W., Schwartz, Martin, Harris, Ben G., Norton, S. J. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | v, 173 leaves : ill., Text |
| Rights | Public, Levi, Viktorya, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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