Orientador: Daniel Galera Bernabé / Coorientador: Glauco Issamu Miyahara / Banca: Dulce Elena Casarini / Banca: Eder Ricardo Biasoli / Resumo: Objetivos: As catecolaminas podem regular diversos efeitos biológicos resultantes do estresse crônico. Estudos demonstram que as catecolaminas podem influenciar a progressão do câncer. No entanto, pouco se sabe sobre o perfil de secreção das catecolaminas em pacientes com câncer de cabeça e pescoço (CCP) e sua associação com as variáveis clinicopatológicas e psicológicas. O presente estudo investigou os níveis plasmáticos pré-tratamento das catecolaminas norepinefrina (NE) e epinefrina (E) em pacientes com câncer de boca e orofaringe e em pacientes com leucoplasia bucal, bem como sua associação com as variáveis clinicopatológicas, biocomportamentais e os sintomas de ansiedade. Pacientes e métodos: Um total de 71 pacientes com carcinoma espinocelular (CEC) de boca, 22 pacientes com CEC de orofaringe e 32 portadores de leucoplasia bucal foram submetidos à coleta de amostras de sangue. Os níveis plasmáticos das catecolaminas NE e E foram mensurados por meio de Cromatografia Líquida de Alta Eficiência com detecção eletroquímica (CLAE-ED) e os níveis psicológicos de ansiedade foram mensurados pelo Inventário de Ansiedade de Beck (IAB). As diferenças nos níveis hormonais entre os grupos foram avaliadas pelo teste ANOVA e análises univariadas e regressões múltiplas foram realizadas para avaliar as associações dos níveis hormonais com as variáveis clinicopatológicas, biocomportamentais e psicológicas. Resultados: As concentrações plasmáticas de NE e E foram significativamente maiores... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Background: Catecholamines may regulate several biological effects resulting from chronic stress. Studies have shown that stress-related catecholamines may affect cancer progression. However, little is known about catecholamines secretion profile in head and neck cancer squamous cell carcinoma (HNSCC) patients and its association with clinicopathological and psychological variables. The present study investigated the pre-treatment plasma levels of catecholamines norepinephrine (NE) and epinephrine (E) in patients with oral and oropharyngeal SCC and patients with oral leukoplakia, as well as their associations with clinicopathological and biobehavior variables and anxiety symptoms. Patients and methods: A total of 71 patients with oral SCC, 22 patients with oropharyngeal SCC and 32 patients with oral leukoplakia were submitted to blood samples. Plasma levels of NE and E were measured by High Performance Liquid Chromatography with electrochemical detection (HPLC-ED) and psychological anxiety levels were measured by the Beck Anxiety Inventory (BAI). Differences in hormone levels among the groups were analyzed by ANOVA test. Univariate and multiple regression analyzes were performed to evaluate the associations of hormonal levels with clinicopathological, biobehavior and psychological variables. Results: Plasma NE and E concentrations were significantly higher in patients with oral and oropharyngeal cancer than oral leukoplakia patients (p<0.05). Oral SCC patients showed NE levels (462.03±47.53 pg/mL) about six times and nine times higher than patients with oropharyngeal SCC (74.46±12.52 pg/mL) and oral leukoplakia (51.69±6.28 pg/mL), respectively. Plasma NE and E levels were positively correlated in patients with oral SCC (p=0.0011), but not in the oropharyngeal SCC and oral leukoplakia groups. Multiple... / Mestre
| Identifer | oai:union.ndltd.org:UNESP/oai:www.athena.biblioteca.unesp.br:UEP01-000891213 |
| Date | January 2017 |
| Creators | Bastos, Daniela Brito. |
| Contributors | Universidade Estadual Paulista (Unesp) Faculdade de Odontologia |
| Publisher | Araçatuba, |
| Source Sets | Universidade Estadual Paulista |
| Language | Portuguese |
| Detected Language | English |
| Type | text |
| Format | 80 f. : |
| Relation | Sistema requerido: Adobe Acrobat Reader |
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