Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, 2008. / Submitted by Kelly Marques (pereira.kelly@gmail.com) on 2009-11-13T18:46:28Z
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Previous issue date: 2008-02 / Os gases derivados do petroleo sao conhecidos por causar danos a saude das pessoas expostas ocupacionalmente, de modo cronico ou agudo. Funcionarios do Laboratorio de Controle de Qualidade dos Combustiveis, da Agencia Nacional do Petroleo-ANP, situada em Brasilia (Brasil), estao expostos a varias substancias quimicas, pois realizam analises para o controle de qualidade nas amostras dos combustiveis coletadas nos 306 postos de abastecimento do Distrito federal. Os monitoramentos citogeneticos desses trabalhadores foram realizados nos linfocitos retirados do sangue periferico e nas celulas esfoliadas da bexiga, extraidas da urina. A frequencia de aberracoes cromossomicas nos linfocitos e a quantidade de micronucleos nas celulas esfoliadas da bexiga foram utilizadas como biomarcadores para analisar o risco genotoxico. Como resultado, observamos aumentos significantes desses biomarcadores, tanto no sangue como na urina, indicando que a exposicao ocupacional aos derivados do petroleo pode estar envolvida nessas alteracoes citogeneticas encontradas. Dentre todas as substancias presentes no petroleo e seus derivados, a fracao benzeno, tolueno e xileno (BTX) e bastante volatil e toxicologicamente mais perigosa ao homem, com riscos conhecidos de carcinogenese. Observou-se tambem uma correlacao direta entre o numero de aberracoes cromossomicas e a frequencia de micronucleo no grupo exposto (r = 0,74). _______________________________________________________________________________ ABSTRACT / It is well-known that vapours from petroleum derivates, specially aromatic compounds such as benzene, toluene and xilene, known as BTX fraction can be hazardous to human health. Chronic and acute exposure to petroleum derivative vapours are associated with several haematological disturbances. This study was carried out in a group of 21 individuals occupationally exposed to petroleum derivative vapours in a Laboratory of Quality Control from the brazilian government. Blood and urine samples were used to analyse chromosome aberration in lymphocytes cells and micronuclei in exfoliated cells from urinary bladder respectively. These results were compared with a control group of 10 non-exposed individuals working in office. Chromosome aberrations and micronuclei frequencies were statistically increased (P < 0.05) in the exposed group. A positive relationship was found between chromosome aberration and micronuclei in the exposed group (r = 0,74).
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unb.br:10482/2880 |
| Date | 02 1900 |
| Creators | Araújo, Ana Elizabeth Oliveira de |
| Contributors | Grisolia, Cesar Koppe |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UnB, instname:Universidade de Brasília, instacron:UNB |
| Rights | info:eu-repo/semantics/openAccess |
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