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hataka_a_dr_botfmvz.pdf: 4222509 bytes, checksum: 67b76ca3561e8fc51c1b1bcc9eddc0f1 (MD5) / Universidade Estadual Paulista (UNESP) / Os tumores de mama representam 50% de todas as neoplasias que acometem as cadelas, com freqüência de duas a três vezes maior que a observada na mulher. O objetivo deste trabalho foi diagnosticar as neoplasias mamárias malignas das cadelas pela citologia aspirativa e histopatologia, para o estagiamento dos tumores e prognóstico dos pacientes. Os cânceres de mama de 32 cadelas foram diagnosticados pela citologia aspirativa e histopatologia. Também foram realizadas colheita de dados epidemiológicos, classificação TNM e analise de sobrevida. Além disso, os resultados obtidos foram comparados com a literatura humana. Foram diagnosticados pela citopatologia e histopatologia; carcinoma complexo (15,63%); carcinoma sólido (15,63%); carcinoma epidermóide (9,37%), fibrossarcoma (9,37%), carcinomas papilares (15,62%), carcinoma de células fusiformes (6,25%), melanoma (6,25%), carcinoma anaplásico (6,25%); carcinossarcoma (3,13%) e carcinoma neuroendócrino (3,13%). A idade e o peso médio foram 9,5 anos e 13,8 kg respectivamente, predominaram os animais sem raça definida, de médio e pequeno porte, com dieta de comida caseira e ração e sem alterações reprodutivas. A classificação TNM revelou a maior parte da amostra como dos estágios III (43,75%) e IV (28,13%). A análise de sobrevida indicou tempo médio de 7,5 meses para o grupo IV e 25 meses para o II. As taxas de sobrevivência para os grupos II, III e IV aos 35 meses foram 67%, 50% e 11% respectivamente. A comparação com dados humanos revela haver correlação entre a morfologia e o comportamento biológico de alguns cânceres. A associação das técnicas diagnósticas utilizadas neste trabalho constituiu fator prognóstico efetivo para cadelas com câncer de mama. Palavras-chave: Câncer de mama; citopatologia: diagnóstico; histopatologia; TMN; prognóstico. / Mammary gland tumors comprise 50% of all neoplasms in female dog which occur three times greater than the level reported in women. Tumor stagement and patient prognosis with cytopathologic and histopathologic diagnostic of female dog breast cancer were the aims of this paper. 32 malignant breast tumors were both fine-needle aspiration and histopathologicaly diagnosed. More over, the TNM system was applied and epidemiological data was compiled. Human breast tumor information was compared with our results. Complex carcinoma (15.63%), solid carcinoma (15.63%), squamous cell carcinoma (9.37%), fibrosarcoma (9.37%), papillary carcinoma (15.62%), spindle cell carcinoma (6.25%), malignant melanoma (6.25%), anaplastic carcinoma (6.25%), carcinossarcoma (3.13%) and neuroendocrine carcinoma (3.13%) were all diagnosed by cytological and histopathological exams. 9.5 years and 13.8 kg were respectively the average age and weight. The predominant status of the bitches was of small and medium size animals, mongrel breed, fed with pet food and other kinds of food and with normal reproductive functions. The TNM system showed that the major part of the females was in stages III (43.75%) and IV (28.13%). The mean time of survival were 7.5 months to stage IV and 25 months to stage II. The survival rate to stages II, III and IV at 35 months were 67%, 50% and 11% respectively. The results compared to human breast data reveal similar biological behavior and morphology to some tumors in both species. In conclusion effective prognostic factors to breast cancer in female dog were established by the association of the diagnostic techniques used. Key words: Breast cancer; cytopathology; diagnosis; histopathology; TMN; prognostic.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unesp.br:11449/101318 |
| Date | January 2004 |
| Creators | Hataka, Alessandre [UNESP] |
| Contributors | Universidade Estadual Paulista (UNESP), Rocha, Noeme Sousa [UNESP] |
| Publisher | Universidade Estadual Paulista (UNESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | 90 f. : il. |
| Source | Aleph, reponame:Repositório Institucional da UNESP, instname:Universidade Estadual Paulista, instacron:UNESP |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -1, -1 |
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