In this work the alkylation of 2-ethylsulfanyl -5-methoxy-4(3H)-pyrimidinone with 4-substituted ω-bromoacetophenones, ethyl 2-bromoalkanoates and 1-bromomethyl-o-carborane was investigated. It was found that reaction of title compounds in the presence of potassium carbonate in boiling acetonitrile yielded O-alkylated derivatives with small amount of N3- and N1-alkylation products. The proportion of O- and N-alkylated products varied depending on the nature of substituent in the 4th position of benzene ring. Alkylation of title compound with ethyl bromoethanoate led to mixture of O-, N3- and N1 alkylated derivatives, while the reaction with ethyl 2-bromopropanoate yielded only O-alkylated isomer. 2-Substituted 4-pyrimidinols with nido-carborane at the side chain were synthesized. The structure of synthesized compounds was confirmed by the data of IR, UV and 1H NMR spectra.
| Identifer | oai:union.ndltd.org:LABT_ETD/oai:elaba.lt:LT-eLABa-0001:E.02~2005~D_20050613_183542-65729 |
| Date | 13 June 2005 |
| Creators | Čepulytė, Simona |
| Contributors | Šalkus, Bronislovas, Gefenas, Vladas, Malinauskas, Albertas, Stankevičiūtė, Živilė, Gefenienė, Audronė, Vitėnienė, Irena, Giraitis, Raimondas, Vilnius Pedagogical University |
| Publisher | Lithuanian Academic Libraries Network (LABT), Vilnius Pedagogical University |
| Source Sets | Lithuanian ETD submission system |
| Language | Lithuanian |
| Detected Language | English |
| Type | Master thesis |
| Format | application/pdf |
| Source | http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050613_183542-65729 |
| Rights | Unrestricted |
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