Alzheimer's disease is the most common dementia disease and the main cause of death. The hallmark is neurofibrillary tangles (abnormal aggregates of tau protein) and beta-amyloid (Aβ) neuritic plaques that leads to impaired cognitive function such as memory loss and learning difficulties. Researchers have discovered that intermittent fasting improves these cognitive abilities, even though eating regularly is recommended for good cognition. This systematic review aims to investigate further if intermittent fasting improves cognitive function in Alzheimer’s disease and if levels of Aβ and tau pathology explain these changes in cognitive function. The research question is: does intermittent fasting improve cognitive abilities in Alzheimer’s disease and does the levels of Aβ and tau pathology explain these cognitive changes? A literature search for articles was performed on three electronic databases: Pubmed, Web of Science, and WorldCat which gave n=744 articles. The cognitive tests showed a trend toward improved memory, learning, and exploratory behavior in Alzheimer’s disease from intermittent fasting. However, the effects on the levels of Aβ and tau pathology were inconsistent, which invites the possibility of a more prominent, underlying issue of Alzheimer's disease.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:his-21588 |
| Date | January 2022 |
| Creators | Ek, Hanna |
| Publisher | Högskolan i Skövde, Institutionen för biovetenskap |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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