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Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders

Magister Pharmaceuticae - MPharm / Neurodegenerative diseases (ND) are chronic and progressive in nature, and
characterized by the gradual loss of neurons in various regions of the central
nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), multiple sclerosis (MS), amyotrophic lateral
sclerosis (ALS) and cerebral ischemia/reperfusion (CIR). They have various
progressive neurodegenerative pathologies that can result in several severe
functional impairments for patients, and ultimately lead to serious health-related
issues. According to more recent data, AD accounts for the most common cause of
dementia and is believed to contribute to approximately 60–70% of cases. AD is thus
seen as the most common form of dementia.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/7885
Date January 2020
CreatorsFourie, Locarno Lawrence
ContributorsJoubert, J
PublisherUniversity of the Western Cape
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
RightsUniversity of the Western Cape

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