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Previous issue date: 2017-04-28 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Bebidas alco?licas s?o popularmente consumidas em diversas culturas humanas. Por?m, o
consumo alco?lico excessivo e a longo prazo pode promover danos sociais, f?sicos e
psicol?gicos de dif?cil revers?o. De fato, o ?lcool exerce diferentes efeitos no organismo.
Baixas concentra??es promovem euforia, relaxamento, e al?vio do estresse/ansiedade
(efeito ansiol?tico), e a abstin?ncia, ap?s doses m?dias cr?nicas, aumentam o
estresse/ansiedade (efeito ansiog?nico), podendo interferir na aprendizagem. No entanto,
h? poucas informa??es sobre como essa droga altera aspectos cognitivos e psicol?gicos em
situa??es de estresse/ansiedade que envolvam aprendizagem. O que demanda investiga??es
aprofundadas com a proposi??o de modelos animais para uso translacional. Diante disso,
caracter?sticas como: f?cil manuten??o e reprodu??o em laborat?rio, homologia gen?tica
superior a 70% ? do genoma humano, e facilidade na administra??o de f?rmacos, tornam o
peixe paulistinha (Danio rerio) um modelo ideal em pesquisas translacionais que
envolvam drogas de abuso. Nesse sentido, o presente trabalho buscou investigar o efeito de
diferentes tratamentos alco?licos (cr?nico e agudo) no desdobramento da resposta de
ansiedade e na aprendizagem associativa aversiva do peixe paulistinha. Para isso, foram
testados os efeitos do ?lcool na aprendizagem associativa aversiva do paulistinha (artigo 1)
e os efeitos do ?lcool e do enriquecimento ambiental (EE) na impossibilidade do peixe
evitar um estressor (artigo 2). Os resultados indicaram que comportamentos tipo-ansiosos
em paulistinha s?o alterados por mudan?as nas concentra??es alco?licas, no regime de
exposi??o ou no ambiente. ?lcool agudo aumenta ansiedade e potencializa a percep??o em
rela??o ao eletrochoque. J? o EE promove efeito ansiol?tico e diminui a percep??o do
eletrochoque. Por fim, sugerimos que esse trabalho serve de base para pesquisas
neurofisiol?gicas gen?ticas e comportamentais sobre os efeitos da intera??o entre drogas
de abuso e ambiente. / Alcoholic beverages are popularly consumed in various human cultures. However,
excessive and long-term alcohol consumption can promote social, physical and
psychological damages that are difficult to reverse. In fact, alcohol has different effects on
the body. Low concentrations promote euphoria, relaxation, and stress/anxiety relief
(anxiolytic effect), and abstinence after chronic medial doses increases stress / anxiety
(anxiety) and may interfere with learning. However, there is little information on how this
drug alters cognitive and psychological aspects in stress/anxiety situations involving
learning. Therefore, in-depth investigations are required with the proposition of
translational animal models. As a result, characteristics such as: easy maintenance and
reproduction in the laboratory, genetic homology up to 70% to that of the human genome,
and ease of administration of drugs, make zebrafish (Danio rerio) an ideal model in
translational research involving drugs of abuse. In this sense, the present study sought to
investigate the effect of different alcoholic treatments (chronic and acute) in the unfolding
of the anxiety response and in the aversive associative learning of zebrafish.For this, the
effects of alcohol in the aversive associative learning of zebrafish (manuscript 1) and the
effects of alcohol and environmental enrichment (EE) on the impossibility of the fish to
avoid a stressor were tested (manuscript 2). The results indicated that anxiety-like
behaviors in zebrafish are altered by changes in alcoholic concentrations, in the exposure
regime or in the environment. Acute alcohol increases anxiety and potentiates the
electroshock perception. While EE promotes anxiolytic effect and decreases the perception
of electroshock. Finally, we suggest that this work serves as a basis for genetic and
behavioral neurophysiological research regarding the effects of the interaction between
drugs of abuse and environment.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/23710 |
| Date | 28 April 2017 |
| Creators | Amorim, Ricardo Rodrigues |
| Contributors | 27831268855, http://lattes.cnpq.br/7859231596449028, Rossato, Janine Inez, 95279490091, http://lattes.cnpq.br/8136970112250481, Freitas, Renato Hajenius Ach? de, 26953405830, http://lattes.cnpq.br/2728329926466893, Silva, Priscila Fernandes, Luchiari, Ana Carolina |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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