The effect of pyridoxine (PN) supplementation on the activities
of erythrocyte alanine aminotransferase (EAlaAT) and aspartate aminotransferase
(EAspAT) was observed in five men, aged 22 to 25 years.
The subjects received a constant diet containing 1.34 mg of vitamin
B-6 Monday through Friday of each week during this five-week study.
Starting on day 6 of week 1, the subjects were given orally 5 mg PN
daily, except on Tuesday and Thursday of each week when they were given
either no PN or 2 mg of vitamin B-6 in the form of crystalline PN or
as food. Basal and pyridoxal phosphate (PLP)-stimulated EAlaAT and
EAspAT activities were determined weekly. Both basal and PLPstimulated
activities of the two enzymes increased after only three
days of PN supplementation and continued to increase throughout the
four weeks of PN supplementation; percent stimulation by PLP added in
vitro decreased concomitantly. It is suggested that the binding of PLP
to erythrocyte apoaminotransferases may be another reservoir for
vitamin B-6. / Graduation date: 1982
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27470 |
| Date | 03 March 1982 |
| Creators | Wang, Ann-gau Nancy |
| Contributors | Miller, Lorraine T. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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