Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

Description

Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

Links & Downloads

1. urn:nbn:de:bsz:14-qucosa-138993
2. 404984878
3. https://tud.qucosa.de/id/qucosa%3A27800
4. https://tud.qucosa.de/api/qucosa%3A27800/attachment/ATT-0/

Tags

info:eu-repo/classification/ddc/540

ddc:540

Additional Fields

Identifer	oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:27800
Date	January 2012
Creators	Linning, Philipp, Haussmann, Ute, Beyer, Isaak, Weidlich, Sebastian, Schieb, Heinke, Wiltfang, Jens, Klafki, Hans-Wolfgang, Knölker, Hans-Joachim
Publisher	Royal Society of Chemistry
Source Sets	Hochschulschriftenserver (HSSS) der SLUB Dresden
Language	English
Detected Language	English
Type	doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Source	Organic & biomolecular chemistry 2012;10:8216–8235, ISSN: 1477-0520
Rights	info:eu-repo/semantics/openAccess
Relation	10.1039/c2ob26103k