Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is
involved in many cellular processes. However, the potential role of PTTG1 in tumor
formation and its prognostic function in human pan-cancer is still unknown. The
analysis of gene alteration, PTTG1 expression, prognostic function, and PTTG1-related
immune analysis in 33 types of tumors was performed based on various databases such
as The Cancer Genome Atlas database, the Genotype-Tissue Expression database, and
the Human Protein Atlas database. Additionally, PTTG1-related gene enrichment analysis
was performed to investigate the potential relationship and possible molecular
mechanisms between PTTG1 and tumors. Overexpression of PTTG1 may lead to
tumor formation and poor prognosis in various tumors. Consequently, PTTG1 acts as
a potential oncogene in most tumors. Additionally, PTTG1 is related to immune infiltration,
immune checkpoints, tumor mutational burden, and microsatellite instability. Thus, PTTG1
could be potential biomarker for both prognosis and outcomes of tumor treatment and it
could also be a promising target in tumor therapy.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84556 |
| Date | 04 April 2023 |
| Creators | Gong, Siming, Wu, Changwu, Duan, Yingjuan, Tang, Juju, Wu, Panfeng |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1664-8021, 843579 |
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