Includes abstract. / Includes bibliographical references. / The WNT pathway is a major developmental pathway that plays an important role in the development of many tumours, including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second commonest bone malignancy in childhood. A recent study on ES cell lines using RT-PCR analysis and biological response assays suggests that an intact WNT pathway exists in ES and that addition of exogenous WNT ligands enhances cell motility. Based on this we hypothesize that the WNT pathway may play a role in the biology of ES/PNET and we aim to investigate this by immunohistochemical stains on archival tissue.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/11479 |
| Date | January 2011 |
| Creators | Wu, Hue-Tsi |
| Contributors | Govender, Dhiren |
| Publisher | University of Cape Town, Faculty of Health Sciences, Division of Anatomical Pathology |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Master Thesis, Masters, MMed |
| Format | application/pdf |
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