Purpose: The purposes of this study were (1) to determine the correlations of adiponectin, leptin, the adiponectin:leptin (A/L) ratio, insulin, BMI, glucose, insulin resistance index (HOMA-IR), and waist circumference in women with PCOS, and (2) to examine the effects of an 8 week supplement of 75 g of dried apples daily and twice a week moderate intensity resistance exercise on these parameters. Methods: Baseline data for 26 women diagnosed with PCOS were analyzed. Of these 26 subjects, 13 completed the intervention study. In a 2X2 factorial design using apples and exercise, 70 g Kellogg's Frosted Mini Wheats was used as the control for the dried apples since it contained similar amounts of fiber and energy. Exercise consisted of twice a week full body routines, using 3 sets of 12 repetitions maximum (12RM). SPSS for Windows, Version 15.0 software was utilized to calculate and determine descriptive statistics, t-tests, Pearson correlations, and one way ANOVA. Results: In subjects with a BMI > 25 (n=13), insulin, HOMA-IR, and leptin were significantly higher (p<0.05), while adiponectin and the A/L ratio were significantly (p<0.05) lower than in the subjects with a BMI < 25 (n=13). In the correlational analyses of the data for all subjects at baseline (n=26), results were as expected in accordance with the literature. Adiponectin and leptin were significantly negatively correlated, but this correlation did not persist after controlling for BMI. There was a trend (p=0.058) towards a negative relationship between the A/L ratio and HOMA-IR (n=26). When separated by BMI, this relationship was not significant in the lean group (BMI <25, n=13), but in the obese group (BMI>30, n=8), the A/L ratio and HOMA-IR were significantly negatively correlated (p=0.048). In the intervention study, fasting serum glucose increased from baseline to endpoint in the cereal groups with and without exercise. Conclusions: The lean women with PCOS in this study did not exhibit the expected negative relationship between A/L ratio and HOMA-IR, suggesting a possible genetic polymorphism in their adipocytes. In terms of the intervention, this study found that 75 grams of dried apples and moderate intensity resistance exercise twice a week did not have any significant effect on any of the parameters measured other than a rise in fasting blood glucose associated with cereal intake in this study group (n=13). More subjects are required to meet the effect size necessary to assess correlations with confidence as well as to determine if the interventions have an effect on the outcomes. / A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements
for the degree of Master of Science. / Fall Semester, 2008. / August 15, 2008. / Lean PCOS, Apple Polyphenol, Polycystic Ovary Syndrome, Adiponectin to Leptin Ratio, Obese PCOS / Includes bibliographical references. / Maria Spicer, Professor Directing Thesis; Mike Overton, Committee Member; Dan McGee, Committee Member.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_253954 |
| Contributors | Bendor, Liran (authoraut), Spicer, Maria (professor directing thesis), Overton, Mike (committee member), McGee, Dan (committee member), Department of Nutrition, Food, and Exercise Science (degree granting department), Florida State University (degree granting institution) |
| Publisher | Florida State University, Florida State University |
| Source Sets | Florida State University |
| Language | English, English |
| Detected Language | English |
| Type | Text, text |
| Format | 1 online resource, computer, application/pdf |
| Rights | This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). The copyright in theses and dissertations completed at Florida State University is held by the students who author them. |
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