This systematic review's goal is to evaluate the efficacy of vitamin D supplementation in helping to manage the nutritional needs of patients diagnosed with prostate cancer. A systematic literature search following the PRISMA guidelines using Scopus, PubMed, and Cochrane databases was conducted to review randomized controlled trials and interventional studies up to 2023. The search strategy targeted randomized controlled trials and intervention studies. The selection process involved screening for study characteristics (study design), participant demographics (prostate cancer patients receiving treatment), intervention details (vitamin D assessment methods, dosages), outcome measures (progression, prognosis, quality of life), and risk estimates (hazard ratios, odds ratios, relative risks) along with covariates adjusted for in the analysis. Data analysis and synthesis included studies assessing vitamin D supplementation's impact on prostate-specific antigen (PSA) levels, tumor progression, osteomalacia, overall survival rates, and quality of life assessments. The literature search yielded a total of 3575 documents. After a preliminary screening of titles and abstracts, 34 full-text studies were examined. In total, nine studies were determined to meet the inclusion criteria. The findings of nine studies suggest a modest but significant association between vitamin D supplementation, reduced PSA levels, slower progression of localized prostate cancer, and improved bone loss. Due to the various treatment options, the overall effects of supplementation on advanced prostate cancer and overall survival were inconclusive. However, this research highlights the potential role of vitamin D in prostate cancer management.
| Identifer | oai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-7104 |
| Date | 10 May 2024 |
| Creators | Cosby, Grier |
| Publisher | Scholars Junction |
| Source Sets | Mississippi State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Theses and Dissertations |
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