Yes / Background: Platelet rich plasma (PRP), processed from autologous peripheral blood, is used to
treat androgenetic alopecia (AGA). Objective: To determine the efficacy of PRP for hair growth
promotion in AGA patients in a randomized, blinded, placebo controlled, pilot clinical trial
(NCT02074943). Methods: The efficacy of an 8 week, 5 session, PRP treatment course was
determined by measuring hair density and hair caliber changes in 10 AGA affected patients. For
each PRP sample, the concentrations of selected growth factors were determined using a
multiplex assay system. The clinical results were then correlated to the growth factor
concentrations in PRP. Results: At 16 weeks, 8 weeks after the last PRP injection, treated areas
exhibited increased mean hair density (+12.76%) over baseline compared to placebo (+0.99%).
Mean hair caliber decreased in both treated and placebo regions (-16.22% and -19.46%
respectively). Serial analysis of PRP significant variability in concentrations between patients.
Overall, there was a positive correlation between GDNF concentration and hair density (p=
0.004). Trends, though not statistically significant, were also observed for FGF2 and VEGF.
Limitations: Small sample size and lack of comparative cohorts receiving protocol variations
limit confidence in the study data. Conclusions: This small pilot clinical trial suggests PRP
treatment may be beneficial for AGA. However, the variable hair growth responses between
patients indicate there is a significant opportunity to improve PRP therapy protocols for hair
growth promotion. The variability in growth factor concentration in PRP suggests
standardization of growth factors post-processing might improve hair growth responses. / RepliCel Life Sciences Inc. (Canada)
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/17752 |
| Date | 27 January 2020 |
| Creators | Siah, T.W., Guo, H., Chu, T., Santos, L., Nakamura, H., Leung, G., Shapiro, J., McElwee, Kevin J. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2020 Wiley This is the peer reviewed version of the following article: Siah TW, Guo H, Chu T et al (2020) Growth factor concentrations in platelet-rich plasma for androgenetic alopecia: an intra-subject, randomized, blinded, placebo-controlled, pilot study. Experimental Dermatology. 29(3): 334-340, which has been published in final form at https://doi.org/10.1111/exd.14074. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving., Unspecified |
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