Lipopolysaccharide (LPS) from Gram-negative bacteria triggers a protective inflammatory response in a normal host. In classical laboratory inbred strains of mice, the Lps locus controls the rate of exponential Salmonella growth in spleen and liver during the early phase of infection through its effect on innate immunity. The gene encoding the Lps mutation was recently identified as the Toll-like receptor 4 (Tlr4 ). Toll-like receptors are a group of evolutionarily conserved pattern recognition receptors involved in the activation of the immune system in response to pathogen. The discovery of mouse Tlr4 as being the gene encoding the Lps mutation provided the possibility of studying the role of this gene in chicken susceptibility to infection with Salmonella typhimurium. To achieve this goal we have cloned the chicken orthologue of mouse Tlr4, determined its sequence, mapped it in the chicken genome and showed its linkage to susceptibility to infection with Salmonella typhimurium in the chicken.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.33797 |
| Date | January 2001 |
| Creators | Leveque, Gary. |
| Contributors | Malo, Danielle (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Human Genetics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001862402, proquestno: MQ78914, Theses scanned by UMI/ProQuest. |
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