While parasympathetic activation is well-known to promote AF, the effects of sympathetic stimulation on AF have not been systematically studied. The present study was designed to study effects of sympathetic stimulation on AF, and the relative effects of sympathetic and vagal stimulation on AF duration for a comparable degree of wavelength and refractory period abbreviation. The results showed that, for a comparable degree of wavelength abbreviation, sympathetic stimulation is much less effective in promoting AF than vagal stimulation. Vagal stimulation markedly increased the heterogeneity of atrial refractoriness, while sympathetic stimulation did not. The heterogeneity in atrial refractory properties may be important in determining the ability to sustain AF and the effect of autonomic interventions on the arrhythmia.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.27370 |
| Date | January 1996 |
| Creators | Liu, Lili, 1964- |
| Contributors | Nattel, Stanley (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pharmacology & Therapeutics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001548785, proquestno: MQ29744, Theses scanned by UMI/ProQuest. |
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