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Relationship between a trial fibrillation and hypertension in rats

The importance of hypertension as a risk factor for the development of AF is well recognized. Despite this leading importance, the role of essential hypertension in providing a substrate for AF is incompletely understood. The present study was undertaken to investigate the possibility of having rats as an adequate animal model for the relationship between hypertension and AF in man and to elucidate the role of hypertension as a risk factor for AF. The results of this study show that structural remodeling especially in the form of increased amount of interstitial fibrosis seems to be the major contributing factor to the AF sustainability. Although it can be concluded that hypertension could accelerate the accumulation of fibrosis which occurs during the normal process of aging, a clear relationship between hypertension and AF in this rat model was not found. Further work in the other animal models of hypertension would be interesting.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.83962
Date January 2005
CreatorsAndalib, Ali
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (Department of Pharmacology and Therapeutics.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: 002261486, proquestno: AAIMR22701, Theses scanned by UMI/ProQuest.

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