In the first study, the effect of intrathecal administration of substance P at T9/T2 on arterial blood pressure and heart rate was studied in acute spinal (T5/T1) transected rats. The results indicate that excitatory effects of substance P on sympathetic output can be elicited in spinal transected rats and that the neural substrate for the effects is intrinsic to the spinal cord. An opioid involvement in suppressing the response to substance P is also confirmed. / In the second study, the role of angiotensin (AII) receptors (AT$ sb1$ and AT$ sb2$) in mediating the effects of intrathecally administered AII on sympathetic output was investigated using DuP 753 and PD 123319, the AT$ sb1$ and AT$ sb2$ receptor antagonists, respectively. The results suggest that at the spinal level, AII expresses its effects on sympathetic output to the heart via the AT$ sb1$ receptor and to the vessels partly via AT$ sb1$ and perhaps also via AT$ sb2$ receptors.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.69754 |
| Date | January 1993 |
| Creators | Park, Patricia Dong-Sook |
| Contributors | Henry, James L. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Physiology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001351831, proquestno: AAIMM91871, Theses scanned by UMI/ProQuest. |
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