Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This complex has been reacted with methionine and N-acetylmethionine at different molar ratios. At high Pt: methionine ratios, chelates with the sulfur and nitrogen atoms of the methionine are dominant; at lower Pt: methionine ratios, a bis-methionine product is formed. The en ligand is displaced by methionine but not N-acetylmethionine.
Identifer | oai:union.ndltd.org:WKU/oai:digitalcommons.wku.edu:theses-1154 |
Date | 01 April 2010 |
Creators | Liao, Yueh Ying |
Publisher | TopSCHOLAR® |
Source Sets | Western Kentucky University Theses |
Detected Language | English |
Type | text |
Format | application/pdf |
Source | Masters Theses & Specialist Projects |
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