Extracts of 16 South African Salvia species commonly used in traditional medicine to treat various microbial infections were investigated
for in vitro antibacterial and antimycobacterial activities using the micro-dilution and respiratory BACTEC method, respectively. The microorganisms
tested include two Gram-positive (Staphylococcus aureus and Bacillus cereus); two Gram-negative (Escherichia coli and Klebsiella
pneumoniae) bacterial strains and the common pathogen responsible for tuberculosis, Mycobacterium tuberculosis. Extracts of the
majority of species exhibited moderate to good antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.03 to
8.00 mg/ml. Promising activity was observed against M. tuberculosis (MIC≤0.50 mg/ml) with S. radula, S. verbenaca and S. dolomitica
displaying the most favourable activity (MIC: 0.10 mg/ml). The antibacterial bioassay-guided fractionation of S. chamelaeagnea resulted in
the isolation of four compounds: carnosol, 7-O-methylepirosmanol, oleanolic acid and its isomer ursolic acid as the active principles against
S. aureus. The in vitro antibacterial and antimycobacterial activities may support the use of Salvia species in traditional medicine to treat
microbial infections.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:tut/oai:encore.tut.ac.za:d1000837 |
| Date | 13 March 2007 |
| Creators | Kamatou, GPP, Van Vuuren, SF, Van Heerden, FR, Seaman, T, Viljoen, AM |
| Publisher | Elsevier |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format | |
| Rights | © 2007 SAAB |
| Relation | South African Journal of Botany |
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