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Anti-tumour activity of trichosanthin and its mechanism of action.

by Wong Yick Fu. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1990. / Bibliography: leaves 201-224. / Acknowledgments --- p.V / Summary --- p.vi / Publications --- p.ix / Statement of Originality --- p.X / List of Abbreviations --- p.xi / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Preamble --- p.2 / Chapter 1.2 --- History of Trichosanthin --- p.6 / Chapter 1.3 --- Preparation of Trichosanthin --- p.8 / Chapter 1.4 --- Chemistry of Trichosanthin --- p.10 / Chapter 1.4.1 --- Primary structure --- p.10 / Chapter 1.4.2 --- Three dimensional structure --- p.12 / Chapter 1.5 --- Pharmacology of Trichosanthin --- p.14 / Chapter 1.5.1 --- Pharmacologic action --- p.14 / Chapter 1.5.2 --- Pharmacokinetics --- p.18 / Chapter 1.5.3 --- Toxicity --- p.21 / Chapter 1.6 --- Clinical Use of Trichosanthin --- p.24 / Chapter 1.6.1 --- Clinical application --- p.24 / Chapter 1.6.2 --- Mechanism of action --- p.29 / Chapter 1.6.3 --- Adverse reactions --- p.31 / Chapter 1.6.4 --- Contraindications --- p.33 / Chapter 1.7 --- Objectives of Project and Organization of Thesis --- p.35 / Chapter Chapter 2 --- Anti-tumour Activity of Trichosanthin In Vitro and In Vivo --- p.37 / Chapter 2.1 --- Cytotoxic Effects of Trichosanthin on Cultured Tumour Cells --- p.38 / Chapter 2.1.1 --- Introduction --- p.38 / Chapter 2.1.2 --- Materials and methods --- p.40 / Chapter 2.1.3 --- Results --- p.49 / Chapter 2.1.4 --- Discussion --- p.59 / Chapter 2.2 --- Effects of Trichosanthin on Co-cultured Cell Lines In Vitro --- p.64 / Chapter 2.2.1 --- Introduction --- p.64 / Chapter 2.2.2 --- Materials and methods --- p.65 / Chapter 2.2.3 --- Results --- p.66 / Chapter 2.2.4 --- Discussion --- p.77 / Chapter 2.3 --- Combination Effects of Trichosanthin with Adriamycin and Cisplatin on Cultured Tumour Cells --- p.80 / Chapter 2.3.1 --- Introduction --- p.80 / Chapter 2.3.2 --- Materials and methods --- p.81 / Chapter 2.3.3 --- Results --- p.84 / Chapter 2.3.4 --- Discussion --- p.93 / Chapter 2.4 --- Effects of Trichosanthin on Choriocarcinoma Cells In Vivo --- p.96 / Chapter 2.4.1 --- Introduction --- p.96 / Chapter 2.4.2 --- Materials and methods --- p.97 / Chapter 2.4.3 --- Results --- p.101 / Chapter 2.4.4 --- Discussion --- p.107 / Chapter 2.5 --- Effects of Trichosanthin Protein and Polysaccharide on Choriocarcinoma Cells In Vitro --- p.110 / Chapter 2.5.1 --- Introduction --- p.110 / Chapter 2.5.2 --- Materials and methods --- p.112 / Chapter 2.5.3 --- Results --- p.114 / Chapter 2.5.4 --- Discussion --- p.117 / Chapter Chapter 3 --- Mechanism of Action of Trichosanthin on Tumour Cells --- p.119 / Chapter 3.1 --- Morphological Study of Effects of Trichosanthin on Cultured Choriocarcinoma Cells --- p.120 / Chapter 3.1.1 --- Introduction --- p.120 / Chapter 3.1.2 --- Materials and methods --- p.121 / Chapter 3.1.3 --- Results --- p.124 / Chapter 3.1.4 --- Discussion --- p.133 / Chapter 3.2 --- Binding of Radiolabelled Trichosanthin with Tumour Cells In Vitro --- p.137 / Chapter 3.2.1 --- Introduction --- p.137 / Chapter 3.2.2 --- Materials and methods --- p.138 / Chapter 3.2.3 --- Results --- p.146 / Chapter 3.2.4 --- Discussion --- p.154 / Chapter 3.3 --- Effects of Trichosanthin on Macromolecule Synthesis of Choriocarcinoma Cells In vitro --- p.159 / Chapter 3.3.1 --- Introduction --- p.159 / Chapter 3.3.2 --- Materials and methods --- p.160 / Chapter 3.3.3 --- Results --- p.163 / Chapter 3.3.4 --- Discussion --- p.167 / Chapter Chapter 4 --- General Discussion --- p.169 / Chapter 4.1 --- Anti-tumour Activity of Trichosanthin --- p.170 / Chapter 4.2 --- Mechanism of Action of Trichosanthin --- p.180 / Chapter 4.3 --- Prospects of Research on Trichosanthin --- p.195 / References --- p.201 / Appendix 1 --- p.225 / Appendix 2 --- p.242

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_318657
Date January 1990
ContributorsWong, Yick Fu., Chinese University of Hong Kong Graduate School. Division of Clinical and Pathological Sciences.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, xii, 246 leaves : ill. ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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