Sinteza i antiproliferativna aktivnost tiazolnih C-nukleozida i njihovih mimetika / Synthesis and Antiproliferative Activity of Thiazole C-Nucleosides and Their Mimics

Description

<p>Ostvarene su vi&scaron;efazne stereospecifične sinteze tiazolnih C-nukleozida, novih analoga, odnosno mimetika tiazofurina polazeći iz D-glukoze i D-ksiloze. Ispitana je <em>in vitro </em>citotoksična aktivnost sintetizovanih C-nukleozida prema odabranim humanim tumorskim ćelijskim linijama (K562, HL 60, Jurkat, Raji, PC 3, HT-29, MCF-7, MDA-MB-231, HeLa i Hs 294T) kao i prema ćelijama normalnih fetalnih fibroblasta pluća (MRC-5).</p> / <p>Multiphase stereospecific synthesis of thiazole C-nucleosides, new analogues and mimics of tiazofurin,&nbsp;has been achives starting from D-glucose and D-xylose.&nbsp;<br />We examined the in vitrocytotoxic activity of&nbsp;synthesized C-nucleosides by selected human tumor cell&nbsp;lines (K562, HL 60, Jurkat, Raji, PC 3, HT-29, MCF-7,&nbsp;<br />MDA-MB-231, HeLa and Hs 294T) and the cells of&nbsp;normal fetal lung fibroblasts (MRC-5).</p>

Links & Downloads

1. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija139841241850239.pdf?controlNumber=(BISIS)77159&fileName=139841241850239.pdf&id=1854&source=NDLTD&language=en
2. https://www.cris.uns.ac.rs/record.jsf?recordId=77159&source=NDLTD&language=en

Tags

Additional Fields

Identifer	oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)77159
Date	08 July 2011
Creators	Spaić Saša
Contributors	Popsavin Mirjana, Ćirin-Novta Vera, Sakač Marija, Ćetković Gordana
Publisher	Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad
Source Sets	University of Novi Sad
Language	Serbian
Detected Language	English
Type	PhD thesis