no / In this work, the possibility of bottom-up creation of a relatively stable aqueous hydrocortisone nanosuspension
using microfluidic reactors was examined. The first part of the work involved a study of the
parameters of the microfluidic precipitation process that affect the size of generated drug particles.
These parameters included flow rates of drug solution and antisolvent, microfluidic channel diameters,
microreactors inlet angles and drug concentrations. The experimental results revealed that hydrocortisone
nano-sized dispersions in the range of 80¿450nm were obtained and the mean particle size could
be changed by modifying the experimental parameters and design of microreactors. The second part of
the work studied the possibility of preparing a hydrocortisone nanosuspension using microfluidic reactors.
The nano-sized particles generated from a microreactor were rapidly introduced into an aqueous
solution of stabilizers stirred at high speed with a propeller mixer. A tangential flow filtration system
was then used to concentrate the prepared nanosuspension. The nanosuspension produced was then
characterized using photon correlation spectroscopy (PCS), Zeta potential measurement, transmission
electron microscopy (TEM), differential scanning calorimetry (DSC) and X-ray analysis. Results showed
that a narrowsized nanosuspension composed of amorphous spherical particles with a mean particle size
of 500±64 nm, a polydispersity index of 0.21±0.026 and a zeta potential of ¿18±2.84mVwas obtained.
Physical stability studies showed that the hydrocortisone nanosuspension remained homogeneous with
slight increase in mean particle size and polydispersity index over a 3-month period.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4851 |
| Date | 2009 June 1922 |
| Creators | Ali, Hany S.M., York, Peter, Blagden, Nicholas |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article |
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