Abstract
Osteoarthritis (OA) is the most common degenerative joint disease and a growing health
problem affecting more than half of the population over the age of 65. It is characterized by inflammation
in the cartilage and synovium, resulting in the loss of joint structure and progressive damage
to the cartilage. Many pro-inflammatory mediators are elevated in OA, including reactive oxygen
species (ROS) such as nitric oxide (NO) and hydrogen peroxide (H2O2). Damaged articular cartilage
remains a challenge to treat due to the limited self-healing capacity of the tissue and unsuccessful
biological interventions. This highlights the need for better therapeutic strategies to heal
damaged articular cartilage. Ozone (O3) therapy has been shown to have positive results in the
treatment of OA; however the use of O3 therapy as a therapeutic agent is controversial. There is
a perception that O3 is always toxic, whereas evidence indicates that when it is applied following
a specified method, O3 can be effective in the treatment of degenerative diseases. The mechanism
of action of O3 therapy in OA is not fully understood and this review summarizes the use of O3
therapy in the treatment of damaged articular cartilage in OA.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:tut/oai:encore.tut.ac.za:d1001856 |
| Date | 05 October 2015 |
| Creators | Manoto, SL, Maepa, MJ, Motaung, SK |
| Publisher | Elsevier |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format | |
| Rights | c 2016 The Authors. Production and hosting by Elsevier B.V. |
| Relation | Saudi Journal of Biological Sciences |
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