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Studies of L-Asparaginase from Lactobacillus Plantarum

This study is concerned with the regulation of Lasparaginase (LA) in the cell-free crude extracts from Lactobacillus plantarum (ATCC8014). A previously reported finding that adenosine triphosphate (ATP) inhibits the action of LA in crude extracts was confirmed. The study was extended to include the mono-, di-, and triphosphates of adenosine, guanosine, cytidine, and uridine. These compounds were also shown to inhibit LA activity. These andother studies revealed that LA appears to be an allosteric type enzyme exhibiting positive homotropism with respect to substrate and heterotropism with respect to the nucleotides tested.
The regulation of LA activity by high energy compounds, when coupled with asparagine synthetaseL suggests a relationship between amide synthesis-amide degradation and the energy levels of the cell.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc663296
Date05 1900
CreatorsNalepka, Edward R.
ContributorsNorton, S. J., Jacobson, Myron, Marshall, James L., 1940-
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatvii, 56 p. : ill., Text
RightsPublic, Nalepka, Edward R., Copyright, Copyright is held by the author, unless otherwise noted. All rights

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