Attention deficit/hyperactivity disorder (ADHD) is a common disease with a worldwide prevalence of 5% on preschool children. It has been reported that ADHD patients have volume variant in partial brain regions. Futhermore, functional magnetic resonance imaging have also been used to detect function variant possibility in particular brain regions. In the last decade, some researchers used diffusion MR imaging to investigate the abnormality of neural fibers in disease involved with central nervous system. In general, the diffusion anisotropy of white matter in both ADHD patients and healthy subjects can be estimated seperately to undergo inter-subject comparison. While previous studies often used the popular ICBM brain template (MNI152), this study applied a self-made template of Taiwan adolescents as the common space of image normailization.
In this work, group comparison of diffusion fractional anisotropy was performing by using two methods, TBSS and VBM. Both manners found a decreased FA in white matter of ADHD subjects compared with normal control group. However, regions detected by different methods showed low reproducibility. The areas of significant difference include inferior longitudinal fasciculus¡Binternal capsule¡Bexternal capsule¡Bsuperior longitudinal fasciculus¡Boptic radiation¡Bsuperior frontal¡Bsuperior region of corona radiata¡Bcorticospinal tract¡Bposterior region of corona radiata / superior longitudinal fasciculus¡Bsuperior fronto-occipital fasciculus¡Banterior region of corona radiata¡Bgenu of corpus callosum nerve fibers.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-1229111-190432 |
| Date | 29 December 2011 |
| Creators | Guo, Sz-Han |
| Contributors | Pin-Chen Yung, Cheng-Wen Ko, Wen-Chau Wu, Tzu-Chao Chuang, Ming-Ting Wu |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-1229111-190432 |
| Rights | unrestricted, Copyright information available at source archive |
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