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A preliminary study of the effects of selective-serotonin re-uptake inhibitors (SSRIs) on central auditory processing

his study compared auditory behavioral and physiological measures among three subject groups: 1) Normal control subjects, 2) subjects who were on a prescribed SSRI for depression, and 3) subjects who were prescribed an SSRI for depression, but were not medicated at the time of testing. Test measures included: Standard audiological tests (audiometry and tympanometry), electrophysiological procedures for analysis of auditory- evoked brainstem and late responses, and standardized behavioral speech tests (SCAN-A, SSI, and the low predictability sentence list of the R-SPIN). Analysis of results indicated a statistically significant increase of group mean amplitude of the ABR peak V, from 15dBnSL to 55dBnSL, in the non-medicated group compared to controls.
Also, the non-medicated group scored significantly less favorably than controls on the most challenging listening condition (-20 MCR) of the SSI, in the left ear. Although other test measures indicated consistent differences between these two groups, they were not, however, significant.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc2853
Date08 1900
CreatorsBishop, Charles E.
ContributorsGopal, Kamakshi V., Lu, Fang-Ling, Henoch, Miriam A., Cokely, Jeffrey A
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
FormatText
RightsUse restricted to UNT Community, Copyright, Bishop Charles E., Copyright is held by the author, unless otherwise noted. All rights reserved.

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