Avian pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis. APEC causes significant economic losses to the poultry industry. In this study, 66 E. coli isolates were collected from broiler flocks across Mississippi and categorized as clinical and non-clinical isolates. Genotypic and phenotypic characterization of virulence factors and antimicrobial resistance profiles of these E. coli were examined. The data disclosed a higher prevalence of virulence genes in clinical isolates than in non-clinical isolates. High differences on the genotypic and phenotypic antimicrobial resistance among clinical and non-clinical isolates were observed. Whole genome sequences of avian E. coli elaborated a diverse range in genetic composition, phylogenic relationship, antimicrobial resistance, and virulence gene profiles. Collectively, the results showed that the virulence factors and phenotypic characteristics of APEC may play a role in the pathogenesis of avian colibacillosis. Therefore, this study provides insight to understand the epidemiological background, microbial behavior, and pathogenesis of APEC.
| Identifer | oai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-6684 |
| Date | 09 December 2022 |
| Creators | Devkota, Priyanka |
| Publisher | Scholars Junction |
| Source Sets | Mississippi State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Theses and Dissertations |
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