A chronic hyperglycemic state often results in neuropathological complications such as peripheral diabetic neuropathy (PDN). PDN is a debilitating medical condition that impacts over half of the US population with diabetes. In this study, we used the model organism Caenorhabditis elegans to determine that glucose-supplemented diet leads to an increased rate of intrauterine egg hatching (IUEH) and the reduction of dopamine and serotonin is sufficient to suppress the glucose-induced IUEH. Moreover, in this research demonstrates that a glucose-supplemented diet impacts serotonin and dopamine-associated behaviors. Additionally, we demonstrate that a diet rich in glucose impacts the structure of the serotonergic neurons HSN and NSM. These findings highlight the utility of the model organism C. elegans in elucidating the impact of a glucose-supplemented diet on the nervous system. Finally, these studies show that a glucose-supplemented diet impacts transgenerational and intergenerational phenotypes as well as changes in the transcriptional profile of subsequent generations.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc2332589 |
| Date | 05 1900 |
| Creators | Ruiz, Manuel Axel |
| Contributors | Padilla, Pamela A., Burggren, Warren W., Azad, Rajeev K., McFarlin, Brian K., Jagadeeswaran, Pudur |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Ruiz, Manuel Axel, Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved. |
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