Embolic materials for the treatment of hypervasularised tumours are often non-degradable hydrogels. In this thesis alginate hydrogel microspheres were synthesised and tested as a potential biodegradable embolic agent. Degradation and compressibility were shown in vitro to be dependent on the mannuronic acid to L-guluronic acid ratio, which was attributed to the affinity of calcium to bind to the different alginate monomers. The microspheres were shown to be deliverable and compatible with non-ionic radiopaque contrast media.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:618988 |
| Date | January 2009 |
| Creators | Forster, Richard Edward John |
| Publisher | University of Brighton |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | https://research.brighton.ac.uk/en/studentTheses/b5663ab9-89c3-4c88-9651-6108219962d1 |
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