It is fitting and proper, I think, to review briefly the circumstances which led to the investigation that is presented herewith as well as what might be expected from such as study. The present project is actually an outgrowth of a previous investigation whose purpose was to determine whether Listeria monocytegenes, or any part thereof, could stimulate the production of sheep erythrocyte agglutinine in rabbits. This initial study has already been reported on (Girard, 1950) and the whole problem has been extensively reviewed by us as a result of this study (Girard and Murray, 1951), reprints of which are submitted. Work was already underway to attempt the isolation of a monocyte-producingagent (MPA) by ourselves in this department from the lipid constituants of the organism, L. monocytogenes, in the Fall of 1949, when an article by N.F. Stanley (1949) appeared that described the isolation thereof. Using his technique we successfully extracted the biologically active material which would, upon intravenous inoculation into rabbits, produce a rapid, marked increase in the number of circulating monocytes (Girard, 1950). Our extraction, however, was made with Listeria monocytogenes 10 XXVIII from Professer E.G.D. Murray’s collection. Upon the receipt of the Australian strain some weeks later and the examination thereof, similar results were obtained, though the Australian variety seemed to be more biologically potent in this respect.[...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.123996 |
| Date | January 1952 |
| Creators | Girard, Kenneth F. |
| Contributors | Murray, E. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Bacteriology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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