As knowledge of evolutionary processes has expanded over the years, we havedeepened our understanding about how they drive organismal, cellular, and molecular
biology and the factors beyond natural selection that are involved. Nevertheless, selection
maintains a role in fixing and maintaining successful adaptations to new niches, whether
from environmental change or organismal migration. Adaptation should not be considered
solely on the level of individual genes and point substitutions as selection occurs on multiple
levels. Examination on these multiple levels can further aid in understanding the constraints
on evolution and how organisms can attain a phenotype.
Here we present two packages of tools for the examination of selection on the
levels of protein structure and genetic pathways as well as on the individual gene and
sequence levels., followed by examples of potential applications. First, we present a
package of Application Programming Interface (API) tools that simplifies use of The Adaptive
Evolutionary Database. Second, we present a package of tools implemented in the Rust
programming language for fast and reliable analysis of phylogenetic data.
Then we describe the phenotypic data and methodology for use of these tools to
analyze evolution on multiple levels, where genomic data is available. A broad scale analysis
of the protein structural properties of evolutionary genetic changes in proteins is developed
and described. We also present an organization of phenotypic data for mammals in the
arctic biome, an ancestral reconstruction of the evolution of the phenotypic traits under
study, and demonstrate a methodology to apply the tool packages to this cohort when
sufficient genomic data is available. / Biology / Accompanied by two compressed .zip files: 1) Titled Charts 2) Appendices
| Identifer | oai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/4753 |
| Date | January 2020 |
| Creators | Northover, David, 0000-0003-2889-1098 |
| Contributors | Liberles, David A. |
| Publisher | Temple University. Libraries |
| Source Sets | Temple University |
| Language | English |
| Detected Language | English |
| Type | Thesis/Dissertation, Text |
| Format | 94 pages |
| Rights | IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | http://dx.doi.org/10.34944/dspace/4735, Theses and Dissertations |
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