Mitral valve prolapse is one subtype of mitral valve disease and is characterized by enlarged leaflets that are often thickened and have disrupted collagen architecture. The increased surface area of leaflets with mitral valve prolapse leads to mitral regurgitation, and there is need for percutaneous treatment options that avoid open-chest surgery. Radiofrequency ablation is one potential therapy in which resistive heating can be used to reduce leaflet size via collagen contracture. One challenge of using radiofrequency ablation to percutaneously treat mitral valve prolapse is maintaining contact between the radiofrequency ablation catheter tip and a functioning mitral valve leaflet. To meet this challenge, a radiofrequency ablation catheter was developed with a cryogenic anchor for attachment to leaflets. The effectiveness of the dual-energy catheter was demonstrated in vitro by examining changes in leaflet biaxial compliance, thermal distribution with infrared imaging, and cryogenic anchor strength. The results indicate that a catheter having combined radiofrequency ablation and cryo-anchoring provides a novel percutaneous treatment strategy for mitral valve prolapse.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03262012-133714 |
| Date | 05 April 2012 |
| Creators | Boronyak, Steven Michael |
| Contributors | W. David Merryman, Robert L. Galloway |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu//available/etd-03262012-133714/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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