It is standard practice in radiation therapy to have two independent calculations for the number of monitor units used in patient treatment plans. The relationship between monitor units and absorbed dose to water is sophisticated for MLC-based IMRT. Verification measurements of absorbed dose to water with ionization chambers in MLC-based IMRT fields remains uncertain and the accuracy of computer modeling is limited by the physics assumptions used. In this thesis, point dose measurements from three cylindrical ionization chambers of different collecting volumes are evaluated against the CORVUS (NOMOS Corporation, Cranberry, PA) finite-size pencil beam algorithm and the PEREGRINE (NOMOS Corporation, Cranberry, PA) Monte Carlo calculation engine. After establishing the characteristics of the chambers and treatment planning system under various beam geometries, dynamic and step and shoot MLC deliveries were evaluated. Between detectors, the smallest volume chamber measured the greatest dose. Compared to measurements, CORVUS and PEREGRINE both underestimated the dose in IMRT fields by approximately 5%. On average PEREGRINE yielded better agreement than CORVUS by 2%.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.84031 |
| Date | January 2005 |
| Creators | Fraser, Danielle J. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002263213, proquestno: AAIMR22723, Theses scanned by UMI/ProQuest. |
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