Understanding bladder mechanics and the changes caused by bladder outlet obstruction is an important task in urology. In this work, bladder mechanics are examined in terms of bladder hydrodynamics: the relation between a perturbing volume applied to the bladder and the evoked pressure change. A PC-based experimental system was built which can generate a computer-controlled perturbation volume and measure volume and pressure signals. / The bladders of six minipigs, three normal and three obstructed, were subjected to stochastic volume perturbations about different average volume levels and evoked pressure changes were measured. The hydrodynamic stiffness transfer function relating volume and pressure was calculated and described by a second-order, lumped parametric model having inertial, viscous and elastic terms. Estimates of the elastic constant (K) increased linearly with volume in both normal and obstructed animals. The rate of increase was substantially greater in the obstructed animals than in the normals. Consequently, this approach shows promise for distinguishing normal and obstructed bladder mechanics.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.26440 |
| Date | January 1994 |
| Creators | Zhang, Jing, 1961- |
| Contributors | Kearney, Robert E. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Engineering (Department of Biomedical Engineering.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001426099, proquestno: MM99991, Theses scanned by UMI/ProQuest. |
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