No / Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2
K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum
values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban-Acree model was used to fit
the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban-Acree
model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the
models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol
+ water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities
were also predicted by a previously established log-linear model of Yalkowsky with the OMRD of 53.8 %.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4853 |
| Date | 01 1900 |
| Creators | Ali, Hany S.M., York, Peter, Blagden, Nicholas, Soltanpour, S., Acree, W.E. Jr., Jouyban, A. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, No full-text in the repository |
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