From Introduction: It was as early as 1904 that Paul Ehrlich propounded the idea of a “magic bullet”. This “magic bullet”, or chemotherapeutic agent, as he also called it, had to meet certain requirements: (a) a high activity against pathogenic micro-organisms; (b) easy absorption by the body; (c) activity in the presence of body fluids and tissue; (d) a low degree of toxicity; (e) must not allow the development of resistant micro-organisms. The discovery of the sulphonamide, Prentosil, by Domagk in 1935 was one of the initial steps in the search for this “magic bullet”. This, together with the production and purification of the antibiotics penicillin, by Fleming, Florey and Chain in 1942 and streptomycin, by Waksman in 1943, heralded a new era in the fight against bacterial infections. The majority of modern antibacterial agents have to a large extent met the requirements of Ehrlich’s ‘magic bullet”. They have however failed to prevent the development of resistant bacterial strains. This has been particularly noticeable in the past twenty years since the sudden emergence of multiple-resistant bacteria, many of which can transfer to several drugs in one step by a process of conjugation. This phenomenon which has serious medical implications has prompted numerous studies on the origin, epidemiology, biochemistry and genetics of transferable drug resistance.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:rhodes/vital:4249 |
| Date | January 1973 |
| Creators | Marcos, David |
| Publisher | Rhodes University, Faculty of Science, Botany |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis, Masters, MSc |
| Format | 114 leaves, pdf |
| Rights | Marcos, David |
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