The culture filtrates of Lancefield group A, Griffith type 12 nephritogenic streptococci have been shown by Reed and Matheson (1954) to produce renal lesions, urinary abnormalities, and sustalned hypertension in rabbits. The nephrotoxic substance is dialysable and can be salted out from the concentrated dialysate at 60-75% of full saturation with ammonium sulfate. Matheson (1957) has shown that this fraction contains a mixture of polypeptides which are nephrotoxic in rabbits and Rhesus monkeys (Reed and Matheson 1960). The polypeptides have been separated electrophoretically and Cheuk (1960) has found that one polypeptide band contains more nephrotoxic activity than the other observable bands. [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.117775 |
| Date | January 1965 |
| Creators | Franklin, Maxine A. |
| Contributors | Matheson, B. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Bacteriology & Immunology. ) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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