Lupus anticoagulants (LA) have been identified as antiphospholipid antibodies which can alter certain membrane-related endothelial activities, resulting in increased thrombogenesis. The effects of LA-containing patient plasmas on selected thrombosis-related endothelial functions were examined; 68% of 25 patient plasmas exhibited significant antiphospholipid antibody (APA) IgG and/or IgM directed against one of the four phospholipids tested in vitro; 44% exhibited anti-endothelial antibody. Eighty percent of plasmas with anti-endothelial IgM exhibited APA reactive with phosphatidyl inositol; antiphospholipid IgG did not correlate well with antiendothelium IgG. Patient plasmas that significantly stimulated EC PGI2 secretion uniformly exhibited anti-phosphatidyl serine IgM.Multiple mechanisms of induction of LA, and strong association of anti-PS and anti-EC antibody with thrombosis and related disorders were observed.Ball State UniversityMuncie, IN 47306
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/183456 |
| Date | 03 June 2011 |
| Creators | Javed, Najma H. |
| Contributors | Walker, Thomas S. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | viii, 77 leaves : ill. ; 28 cm. |
| Source | Virtual Press |
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